Y chromosome microdeletion screening using a new molecular diagnostic method in 1030 Japanese males with infertility

O-4: Association of Y Chromosome Microdeletion with Spermatogenic Impairment and Infertility in Human Males with High Concentration of Seminal Hexachlorocyclohexane (HC)

Background: The Y chromosome microdeletion is one of the best-documented causes of male infertility but the factors responsible for Y chromosome microdeletions in spermatozoa remain unresolved. However, the environmental pollutants are known to damage DNA in differentiating and maturing germ cells in the male reproductive tract. In view of this, the objective of the present study was to explore...

Y Choromosomal Microdeletion Screening in The Workup of Male Infertility and Its Current Status in India

Correlation between Y chromosome microdeletion and male infertility.

Dyszoospermia due to genetic factors is the leading cause of male infertility. To explore the correlation between azoospermia factor (AZF) microdeletion of the Y chromosome and male infertility, we evaluated AZF microdeletion on the long arm of the Y chromosome in 166 infertile males and 50 fertile males using multiplex polymerase chain reactions amplification and gel electrophoresis. The resul...

y choromosomal microdeletion screening in the workup of male infertility and its current status in india

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Y Choromosomal Microdeletion Screening in The Workup of Male Infertility and Its Current Status in India

Spermatogenesis is an essential stage in human male gamete development, which is regulated by many Y chromosome specific genes. Most of these genes are centred in a specific region located on the long arm of the human Y chromosome known as the azoospermia factor region (AZF). Deletion events are common in Y chromosome because of its peculiar structural organization. Astonishingly, among the sev...